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当前位置: 首页 > 产品中心 > > Encapsula/Standard Doxosome™ Kit-Doxorubicin Liposomes (PEGylated)/DOX-3000-

Encapsula/Standard Doxosome™ Kit-Doxorubicin Liposomes (PEGylated)/DOX-3000-

Encapsula/Standard Doxosome™ Kit-Doxorubicin Liposomes (PEGylated)/DOX-3000-
  • Encapsula/Standard Doxosome™ Kit-Doxorubicin Liposomes (PEGylated)/DOX-3000-
商品介绍

Description

ThekitiscomposedofonevialofPEGylateddoxorubicinliposomesandonevialofPEGylatedcontrolliposomes. PEGylateddoxorubicinliposomeformulationissimilar tocommercialDoxil®insize,lipidcompositionandtheamountofencapsulateddrug.Theformulationisforresearchpurposesonlyandforinjectiontolaboratoryanimals.DoxorubicindrugisalreadyloadedintotheliposomesusingremoteloADIngbyammoniumsulfategradient.Theformulationisreadyforinjection. ThecontrolformulationofPEGylateddoxorubicinissimilartoPEGylateddoxorubicininsizeandlipidcomposition,butitdoesnotcontaindoxorubicindrug.Theformulationismadeinammoniumsulfategradient.

Surfacereactiveliposomeformulationssuitableforconjugationtovariousantibodies,proteins,peptidesandligandsarealsoavailable.Formoreinformationaboutsurfacereactiveliposomes(Immunsome®)seehere.

Formoreinformationaboutsurfacereactivedoxorubicinliposomes(Immundox®)suitableforconjugationseehere.

DownloadProductInsertDownloadSafetyDatasheet(SDS)

FormulationInformation

StandardDoxosome™Kit-DoxorubicinLiposomes(PEGylated)

2-VialKitforStandardDoxosome™(PEGylated)Specification
Vial1PreformedliposomescomposedofHSPC:Cholesterol:DSPE-PEG(2000)(57:38:5molarratio)
Vial2PreformedliposomescomposedofHSPC:Cholesterol:DSPE-PEG(2000)(57:38:5molarratio)
LipidCompositionforVial1Concentration(mg/ml)Concentration(mM)MolarRatioPercentage
Total15.96mg/ml21.62mM100
HydrogenatedSoyPC9.5812.2257
Cholesterol3.191.1438
DSPE-PEG(2000)3.198.265
Buffers,LiposomeSizeandEncapsulatedDrugConcentrationforVial1Specification
InsideBufferAmmoniumSulfate
OutsideBufferHistidine/SucroseBuffer
pH6.5
LiposomeSize80-100nm
EncapsulatedDoxorubicin2mg/ml(3.45mM)
LipidCompositionforVial2Concentration(mg/ml)Concentration(mM)MolarRatioPercentage
Total15.96mg/ml21.62mM100
HydrogenatedSoyPC9.5812.2257
Cholesterol3.191.1438
DSPE-PEG(2000)3.198.265
BuffersandLiposomeSizeforVial2Specification
InsideBufferAmmoniumSulfate
OutsideBufferHistidine/SucroseBuffer
pH6.5
LiposomeSize80-100nm

LiposomeParticleCalculator

Doxorubicinliposomesareunilamellarandsizedto100nm.Themolarconcentrationofliposomeis21.62mM.Byhaving liposomediameter(nm)andlipidconcentration(µM),youcancalculatethetotalnumberofthelipidsinoneliposomeandthenumberoftheliposomesinonemilliliteroftheliposomesolution.Tousethecalculatorclick here.

Appearance

Doxosome™isared,andDoxosome™Controlisawhitetranslucentliquidbothmadeofnanosizeunilamellarliposomes.Usually,duetothesmallsizeofliposomes,nosettlingwilloccurinthebottomofthevial.Theliposomesarepackagedinambervials.

EducationalVideo

Ordering/ShippingInformation

  • Allliposomebasedformulationsareshippedonblueiceat4°Cininsulatedpackagesusingovernightshippingorinternationalexpressshipping.
  • LiposomesshouldNEVERbefrozen.Icecrystalsthatforminthelipidmembranecanrupturethemembrane,changethesizeoftheliposomesandcausetheencapsulateddrugtoleakout.Liposomesinliquidformshouldalwaysbekeptintherefrigerator.
  • ClientswhoorderfromoutsideoftheUnitedStatesofAmericaareresponsIBLefortheirgovernmentimporttaxesandcustomspaperwork.EncapsulaNanoSciencesisNOTresponsibleforimportationfeestocountriesoutsideoftheUnitedStatesofAmerica.
  • WestronglyencouragetheclientsinJapan,Korea,TaiwanandChinatoorderviaadistributor.Toughcustomsclearanceregulationsinthesecountrieswillcausedelayincustomclearanceoftheseperishableformulationsifordereddirectlythroughus.Distributorscaneasilyclearthepackagesfromcustoms.Toseethelistofthedistributorsclickhere.
  • ClientsorderingfromuniversitiesandresearchinstitutesinAustraliashouldkeepinmindthattheliposomeformulationsaremadefromsyntheticmaterialandtheformulationsdonotrequirea“permittoimportquarantinematerial”.LiposomesareNOTBIOLOGicalproducts.
  • Ifyouwouldlikeyourinstitute’sFedExorDHLaccounttobechargedforshipping,thenpleaseprovidetheaccountnumberatthetimeofordering.
  • EncapsulaNanoScienceshasnocontroloverdelaysduetoinclementweatherorcustomsclearancedelays.YouwillreceiveaFedExorDHLtrackingnumberonceyourorderisconfirmed.ContactFedExorDHLinadvanceandmakesurethatthepaperworkforcustomsisdoneontime. AllsubsequentshippinginquiriesshouldbedirectedtoFederalExpressorDHL.

StorageandShelfLife

Storage

Doxosome™productsshouldalwaysbestoredatinthedarkat4°C,exceptwhenbroughttoroomtemperatureforbriefperiodspriortoanimaldosing.DONOTFREEZE.IfthesUSPensionisfrozen,theencapsulateddrugcanbereleasedfromtheliposomesthuslimitingitseffectiveness.Inaddition,thesizeoftheliposomeswillalsochangeuponfreezingandthawing.

ShelfLife

Doxosome™ismadeondailybasis.Thebatchthatisshippedismanufacturedonthesameday.Itisadvisedtousetheproductswithin4monthsofthemanufacturingdate.

Referencesandbackgroundreading

1.HermansonGT.Bioconjugatetechniques.Academicpress;2013Jul25.

2.TorchilinV,WeissigV,editors.Liposomes:apracticalapproach.OxfordUniversityPress;2003Jun5.

3.GrabarekZ,GergelyJ.Zero-lengthcrosslinkingprocedurewiththeuseofactiveesters.Analyticalbiochemistry.1990Feb15;185(1):131-5.

4.YanL,CraytonSH,ThawaniJP,AmirshaghaghiA,TsourkasA,ChengZ.ApH‐ResponsiveDrug‐DeliveryPlatformBasedonGlycolChitosan–CoatedLiposomes.Small.2015Oct1;11(37):4870-4.

5. Silva-LópezEI,EdensLE,BardenAO,KellerDJ,BrozikJA.ConditionsforliposomeadsorptionandbilayerformationonBSApassivatedsolidsupports.Chemistryandphysicsoflipids.2014Oct31;183:91-9.

6.HazraM,SinghSK,andRayS.SurfaceModificationofLiposomalVaccinesbyPeptideConjugation.JournalofPharmaSciTech,2011;1(1):41-47.

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